Gaston Ramon
(September 30, 1886 - June 8, 1963)
Born in France
Years of Discovery: 1920s -1930s
Gaston Ramon. Photograph. Wellcome V0027053Veterinarian Developed Two Vaccines - Diphtheria and Tetanus

Alfort Veterinary School is where Gaston Ramon got his start in medicine. And, given the nature of scientific research, it makes perfect sense. Animals are critical to the research and discovery of new treatments and Ramon's specialty was the study of serums. Ramon put his training to good use, and he was the final link in the chain of development of an effective vaccine to fight diphtheria. While others had already identified the diphtheria and tetanus toxins, Ramon set about producing safe antitoxins for both the diphtheria and tetanus toxins. His discovery allowed the antitoxins to be mass-produced, providing the first effective means of combating diphtheria on a wide-scale basis.

Diphtheria is a horrible disease, often referred to as the "strangling angel," because of the suffocating membrane that can form over the throat and tonsils. It's a highly infectious disease, typically spread from person to person through coughing or sneezing. Initial symptoms appear two to five days after infection and may include a sore throat, swollen glands, hoarseness, difficulty breathing, and fever. Some people may suffer only a mild reaction, but diphtheria may be fatal for others. It is especially life-threatening to children - up to 20% may die.  Before a vaccine, it killed 15,000 people a year in the U.S. The complications include toxic damage to the heart muscles (diphtheric myocarditis) and to the peripheral nerves (neuritis). Diphtheria is rare in developed nations, thanks to widespread vaccination programs, but continues to be a serious threat in developing nations.

Formaldehyde would seem like an unlikely resource in developing a life-saving vaccine. But, that is exactly the critical component Ramon brought to his research. He discovered that by degrading the diphtheria toxin with formalin (an aqueous solution of 40 percent formaldehyde) he could produce a stunning result: an antitoxin weakened to the point it would not cause active disease, yet still potent enough to produce an immune response. This was the critical breakthrough. These vaccines are known as "anatoxins," or "toxoids," and continue to be the basis of the diphtheria antitoxins produced today.  Canada was among the first nations that implemented mass immunization programs. By the 1930s the vaccine became common in the U.S. and deaths plummeted. 

The adage "blood is thicker than water" seems especially apt in Ramon's case. Not only did he specialize in the study of serums, he also married into the family of one of the leading researchers of his day. His wife was the great niece of Emile Roux, a student and coworker of Louis Pasteur. Roux was instrumental in the founding of the Pasteur Institute where Ramon completed his breakthrough in the diphtheria vaccine. Roux himself did significant work in the development of a serum therapy against diphtheria - a foundation upon which his great niece's husband successfully built.

But Ramon was not finished.  He teamed with a medical doctor, Christian Zoeller to bring his formalin method to tetanus.  Together, they produced a vaccine for it in 1926.  Then in the 1930s they developed a method of combining vaccines so that one shot would provide prevention of diphtheria and tetanus. 

 

Written by science writer, Tim Anderson

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Snippets
Three U.S. Presidents had children who died from diphtheria: Abraham Lincoln, James Garfield and Grover Cleveland.

In 1903 one Kansas family with nine children lost all but one child to diphtheria within a month.  

Since 2004 there have been only two cases of diphtheria in the U.S. 100 years ago in 1921, with a U.S. population one third of todays, diphtheria killed 206,000, mostly children. 

The diphteria vaccine does not target the bacteria that causes the disease, but binds to and neutralizes the bacteria's toxin.


Another Lifesaving Scientist on Our List Made a Tetanus Advance

Thomas Peebles, who is on our list for helping develop the Measles Vaccine, also researched the tetanus vaccine. At the time tetanus was a yearly vaccine. He found that the doses were as much as 2,500 times the amount needed.  Then he demonstrated that a smaller dosed booster shot every ten years would suffice, saving lots of poked arms.  


Vaccines are Ubiquitous & Omnipresent Throughout Our Lives
It is bizarre that vaccines are controversial, when virtually everyone has had vaccines. The average person born today may get 70+ vaccines in their lifetime. 

  • There are 31 childhood vaccines (counting booster shots). Over 90% of people have received some of these vaccines.

Virtually everyone constantly benefits from vaccines

  • Did you know that all beef, poultry, and pork you eat comes from vaccinated animals?
  • And that all horses, dogs, cats, and zoo animals are vaccinated?
  • Who wants to live in a world where you can’t pet your friends’ dog because it may not have been vaccinated, and may have rabies?

Links to More About the Scientist & the Science
Gaston Ramon's Wikipedia Page
https://en.wikipedia.org/wiki/Gaston_Ramon