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Norbert Hirschhorn

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Norbert Hirschhorn
(dob - )
Born in
Year of Discovery: 1968

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His Groundlaying Work Saved Millions of Cholera and Diarrhea Victims

Hirschhorn was both visionary and practical. When he joined the cholera researchers in Dacca, East Pakistan (Bangladesh) he began studying the relationship between cholera and intestinal enzymes. The team was conducting studies on a new therapy known as Oral Rehydration Therapy (ORT). The only current available treatment to combat the dehydration resulting from cholera was IV therapy, a costly and highly technical protocol. ORT proposed to treat patients with a simple fluid mixture they would drink. It was after seeing the initial success of David Sachar's testing of sodium function that Hirschhorn became the driving force behind Oral Rehydration Therapy (ORT) research. The visionary part of him saw the potential for a revolutionary medical breakthrough, and the practical side saw the dwindling supply of IV therapy supplies. His push to conduct clinical trials provided pivotal momentum to ORT, a treatment protocol credited with saving over 50 million lives.


Cholera is a deadly disease that spread from the Ganges delta in India in the 1800s to the rest of the world. It's been responsible for seven pandemics (a worldwide epidemic), resulting in millions of deaths. One of the primary means by which it kills is dehydration, as a result of severe diarrhea and vomiting. In fact, cholera can take someone's life in as little as four hours following onset of symptoms. Undeveloped nations are particularly at risk, as lack of pure drinking water combined with inadequate sanitation facilities allows the disease to spread rapidly. Until the mid-1960s the only accepted treatment was intravenous therapy, a costly and highly technical method. Oral Rehydration Therapy (ORT) burst onto the scene as a lifesaving alternative thanks to the efforts of Norbert Hirschhorn, David Sachar, and others. Hirschhorn and Sachar expanded upon the work previously completed by Robert Phillips. Though Phillips had come painfully close to proving the effectiveness of ORT several years earlier, he became disillusioned when a clinical trial he directed resulted in the death of several patients. Ironically, it was under Phillip's directorship that Hirschhorn and Sachar completed their work on ORT. Their findings confirmed a simple mixture of water, glucose, and sodium given orally was effective in fighting cholera.

Hirschhorn's colleague David Sachar had devised an apparatus that allowed him to test the body's transport of sodium, a critical factor in fighting dehydration. This proved that even cholera patients retain the ability to transport sodium when afflicted by cholera, and the process was enhanced by glucose. Sachar was quite pleased - Hirschhorn was inspired. He immediately saw the link between this finding and the earlier work of his director, Robert Phillips. Hirschhorn was convinced this retained ability was the key to maintaining a positive hydration level - that cholera patients could indeed be given sufficient oral fluids to replace those they lost through diarrhea and vomiting. But, he faced a surprising hurdle. Both Phillips and Sachar resisted. Sachar felt it would be "premature" to conduct trials. Phillips, having conducted his own failed trial on ORT resulting in several patient deaths, was staunchly against the idea. But, Hirschhorn persisted and used the clinic's dwindling IV therapy supplies as leverage. In the end, he got approval and moved ahead. He tested ORT on six deathly ill cholera patients beginning in late 1966. Hirschhorn confirmed that cholera patients treated with ORT achieved a "net positive" hydration level, effectively absorbing more fluid than they eliminated. When he presented his findings in Dacca, one of the plantation doctors hailed ORT as being one of the most profound cholera treatment developments of the century. Hirschhorn's work laid the foundation for his successors in Dacca, David Nalin and Richard Cash, to make Oral Rehydration Therapy the standard means of treating cholera.

A visionary, a pragmatist - a poet... Hirschhorn is a unique combination of gifted scientist and accomplished poet. In addition to his medical background, Hirschhorn holds an MFA from Vermont College. He was nominated for a Pushcart Prize, and won the 1998 Chester H. Jones Foundation National Poetry Competition.

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Introduction by Tim Anderson

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Table of Contents

Introduction
Links to More Information About the Scientist
Key Insight
Key Experiment or Research
Key Contributors
Quotes by the Scientist
Quotes About the Scientist
Anecdotes
Fun Trivia About The Science
The Science Behind the Discovery
Personal Information
Science Discovery Timeline
Recommended Books About the Science
Books by the Scientist
Books About the Scientist
Awards
Major Academic Papers
Curriculum Vitae
Links to Science and Related Information on the Subject
Sources

 








Links to More About the Scientist & the Science

Press release announcing Hirschhorn's winning the 2002 Pollin Prize:
http://nyp.org/news/hospital/2002-pollin-prize.html

Chapter in a book discussing Oral Rehydration Therapy and Hirschhorn:
Oral Rehydration Therapy and Hirschhorn

Hirschhorn's poetry website:
http://www.bertzpoet.com/





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Key Insight




Key Experiments or Research

 



Key Contributors

The Team
Explore other scientists who furthered this lifesaving advance.

Lifesavers Who Developed Oral Rehydration Therapy
Robert Phillips
His early experiments laid the groundwork for Oral Rehydration Therapy.
David Nalin
Had the key insight ORT would work if the volume of solution patients drank matched the volume of their fluid losses.
Richard Cash
Provided crucial collaboration, working with Nalin on the key experiments.
David Sachar
Proved that coupled glucose/sodium/water absorption were intact in cholera patients.




Quotes by the Scientist




Quotes About the Scientist




Anecdotes




Fun Trivia About the Science




The Science Behind the Discovery



Personal Information



Scientific Discovery Timeline




Recommended Books About the Science




Books by the Scientist




Books About the Scientist

 



Awards




Major Academic Papers Written by the Scientist



Curriculum Vitae



Links to Information on the Science





Sources/References