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Norman Heatley

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Norman Heatley
(January 10, 1911 - January 6, 2004)
Born in England
Year of Discovery: 1940

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Engineered Methods to Grow Penicillin, Crucial to Making Antibiotic Treatment Usable 

Heatley joined the famous Florey research team in 1936 after receiving his PhD from Cambridge. Though a rather quiet individual, he would have a monumental impact on the development of penicillin. Heatley was the junior member of the research team but, without his contributions, it's unlikely they would have been successful. Heatley's first breakthrough was in figuring out how to remove the active penicillin from within the liquid produced by the mold culture. Once this was achieved, he faced the difficulty of producing sufficient quantities of penicillin to begin testing. Once again, Heatley used his ingenuity, utilizing every conceivable type of container from discarded glass bottles to ceramic bedpans to culture the penicillin mold. His efforts helped pave the way for the development of penicillin, credited with saving over 80 million lives. 

Heatley was an insightful biochemist, whose quiet nature served him well in his collaboration with his more assertive colleagues. But, though soft-spoken, Florey and his team came to rely on Heatley's genius to solve the most complex issues. The team discovered that adding ether helped isolate the penicillin. But, it was Heatley who figured out how to then extract the active penicillin from the ether solution, by changing the pH. Heatley also directed the effort to produce sufficient quantities of penicillin to begin trials. He set up a makeshift production facility, in the midst of World War II, with few supplies readily available. When a glass manufacturer couldn't produce the culture vessels he needed, he remembered reading about the production of ceramics as a boy, and was convinced he could make a fired ceramic vessel work. He designed the vessel's dimensions and contacted a ceramics company in an English region known as The Potteries to produce them. Heatley even picked up the first batch of 174 himself, in a borrowed van, just two days before Christmas, 1940. This simple production facility produced enough penicillin to conduct the first human trials. Following their early success, Heatley accompanied Florey to the United States, where they completed the necessary arrangements to make penicillin available on a wide-scale basis. By D-Day, in June of 1944, there was enough penicillin available to treat all 40,000 soldiers injured in the Normandy invasion.

Fleming, Florey, and Chain received the Nobel Prize in Medicine in 1945 for the discovery of penicillin - there was no mention of the critical contributions that Heatley had made. But, in 1991, almost 50 years later, Oxford University finally recognized the significance of Heatley's work. Oxford awarded Heatley an honorary doctorate of medicine - one of only two such doctorates awarded to non-medical people in the university's 900-year history.

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Introduction by Tim Anderson



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Table of Contents

Introduction
Links to More Information About the Scientist
Key Insight
Key Experiment or Research
Key Contributors
Quotes by the Scientist
Quotes About the Scientist
Anecdotes
Fun Trivia About The Science
The Science Behind the Discovery
Personal Information
Science Discovery Timeline
Recommended Books About the Science
Books by the Scientist
Books About the Scientist
Awards
Major Academic Papers
Curriculum Vitae
Links to Science and Related Information on the Subject
Sources

 








Links to More About the Scientist & the Science

Science Watch overview of Heatley's work with penicillin:
http://archive.sciencewatch.com/interviews/norman_heatly.htm

Wikipedia entry:
http://en.wikipedia.org/wiki/Norman_Heatley

guardian.co.uk obituary:
http://www.guardian.co.uk/news/2004/jan/08/guardianobituaries.highereducation




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Key Insight




Key Experiments or Research

 



Key Contributors

The Team
Explore other scientists who furthered this lifesaving advance.

Lifesavers: Penicillin

Alexander Fleming
Discovered penicillin, after returning from vacation and finding an unusual mold growing in his culture plates.
Howard Florey
The real brain behind the discovery of penicillin.
Ernst Chain
He refined penicillin, allowing for mass production of the world's first antibiotic.




Quotes by the Scientist




Quotes About the Scientist




Anecdotes




Fun Trivia About the Science




The Science Behind the Discovery



Personal Information



Scientific Discovery Timeline




Recommended Books About the Science




Books by the Scientist




Books About the Scientist

 



Awards




Major Academic Papers Written by the Scientist



Curriculum Vitae



Links to Information on the Science





Sources/References